P53: FROM FUNDAMENTAL BIOLOGY TO CLINICAL APPLICATIONS IN CANCER

p53: From Fundamental Biology to Clinical Applications in Cancer

p53 tumour suppressor gene is our major barrier against neoplastic transformation.It is involved in many cellular functions, including cell cycle USB Port arrest, senescence, DNA repair, apoptosis, autophagy, cell metabolism, ferroptosis, immune system regulation, generation of reactive oxygen species, mitochondrial function, global regulation of g

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Open Partial Horizontal Laryngectomy as a Conservative Salvage Treatment for Laser-Recurrent Laryngeal Cancer: A Multi-Institutional Series

Early-stage laryngeal cancer (T1-T2) is commonly treated with organ-preserving techniques such as transoral laser microsurgery (TOLMS) or radiation therapy (RT), both providing comparable oncological outcomes but differing in functional results.Local recurrence occurs in approximately 10% of cases, making salvage surgery a crucial therapeutic optio

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Pre-Inscribed Laser Surface Pattering for Increased Joining Strength in Laser Fusion Bonding of CFRP and Zinc-Coated Steel

In this study, we present improved fusion-bonding strength results between carbon fiber-reinforced polyetheretherketone (CFR-PEEK) and zinc-coated steel through the introduction of pre-inscribed laser surface patterns.Optimized laser welding parameters, including laser power, focal position, pitch, number of passes, and clamping pressure, are prese

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Disastrous cerebral and ocular vascular complications after cosmetic facial filler injections: a retrospective case series study

Abstract Soft tissue filler injections are among the most popular facial rejuvenation methods.Cerebral infarction and ophthalmic artery occlusion are rare and catastrophic complications, especially when facial cosmetic fillers are injected by inexperienced doctors.Radiologists and plastic surgeons need to increase their awareness of the complicatio

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